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Assay Detail

CHEMBL4411104

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine GRK2 using tubulin as substrate measured after 4 hrs by [gamma-32P]-ATP assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Beta-adrenergic receptor kinase 1 (CHEMBL3711550)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Structure-Based Design of Selective, Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors.
Rowlands RA, Cato MC, Waldschmidt HV, Bouley RA, Chen Q, Avramova L, Larsen SD, Tesmer JJG, White AD.
ACS Med Chem Lett (2019) 10 : 1628 -1634
PubMed 31857838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.48 6.17

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4456539 1 6.17
CHEMBL4576822 1 5.68
CHEMBL4475305 1 5.57
CHEMBL4569321 1 5.54
CHEMBL4456130 1 5.50
CHEMBL4450181 1 4.41
CHEMBL4449730 1 -
CHEMBL4464632 1 -
CHEMBL4543927 1 -
CHEMBL4536595 1 -
CHEMBL4578499 1 -
CHEMBL4517792 1 -
CHEMBL4557065 1 -
CHEMBL4447191 1 -
CHEMBL4524355 1 -
CHEMBL4592746 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4456539 IC50 = 680.0 nM 6.17
CHEMBL4576822 IC50 = 2100.0 nM 5.68
CHEMBL4475305 IC50 = 2700.0 nM 5.57
CHEMBL4569321 IC50 = 2900.0 nM 5.54
CHEMBL4456130 IC50 = 3200.0 nM 5.50
CHEMBL4450181 IC50 = 39000.0 nM 4.41
CHEMBL4449730 IC50 > 100000.0 nM -
CHEMBL4464632 IC50 > 100000.0 nM -
CHEMBL4543927 IC50 > 100000.0 nM -
CHEMBL4536595 IC50 > 100000.0 nM -
CHEMBL4578499 IC50 > 100000.0 nM -
CHEMBL4517792 IC50 > 100000.0 nM -
CHEMBL4557065 IC50 > 100000.0 nM -
CHEMBL4447191 IC50 > 100000.0 nM -
CHEMBL4524355 IC50 > 100000.0 nM -
CHEMBL4592746 IC50 > 100000.0 nM -