Assay Detail
Binding
CHEMBL4411347
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Inhibition of tyrosinase (unknown origin)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of Melanogenesis: An Updated Review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.99 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL394855 | — | — | 1 | 7.16 |
| CHEMBL465880 | MORACHALCONE A | — | 1 | 7.10 |
| CHEMBL4239110 | — | — | 1 | 6.77 |
| CHEMBL458395 | — | — | 1 | 6.01 |
| CHEMBL4436373 | — | — | 1 | 5.33 |
| CHEMBL4441954 | — | — | 1 | 5.32 |
| CHEMBL4467559 | — | — | 1 | 5.10 |
| CHEMBL512578 | MORACIN M | — | 1 | 5.10 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | - |
| CHEMBL4437059 | — | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL394855 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL465880 | MORACHALCONE A | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4239110 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL458395 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4436373 | — | IC50 | = | 4620.0 | nM | 5.33 |
| CHEMBL4441954 | — | IC50 | = | 4770.0 | nM | 5.32 |
| CHEMBL4467559 | — | IC50 | = | 7890.0 | nM | 5.10 |
| CHEMBL512578 | MORACIN M | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL165 | RESVERATROL | IC50 | = | 250000.0 | nM | - |
| CHEMBL4437059 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 164000.0 | nM | - |