Assay Detail
Binding
CHEMBL4411368
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction in melanin synthesis after 2 hrs by spectrophotometric analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of Melanogenesis: An Updated Review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.35 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | — | 1 | 7.52 |
| CHEMBL10 | SB-203580 | — | 1 | 7.47 |
| CHEMBL17331 | PD-169316 | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278041 | SB-202190 | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL10 | SB-203580 | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL17331 | PD-169316 | IC50 | = | 89.0 | nM | 7.05 |