Assay Detail
Binding
CHEMBL4411615
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Binding affinity to 5'-Biotinylated-AR1 G-quadruplex oligonucleotide (unknown origin) by SPR analysis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Down-Regulation of the Androgen Receptor by G-Quadruplex Ligands Sensitizes Castration-Resistant Prostate Cancer Cells to Enzalutamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.35 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468209 | — | — | 1 | 7.75 |
| CHEMBL4526946 | — | — | 1 | 7.67 |
| CHEMBL4565909 | — | — | 1 | 7.47 |
| CHEMBL4566017 | — | — | 1 | 7.42 |
| CHEMBL4452581 | — | — | 1 | 7.38 |
| CHEMBL4558509 | — | — | 1 | 7.36 |
| CHEMBL4436828 | — | — | 1 | 7.03 |
| CHEMBL4453055 | — | — | 1 | 6.74 |
| CHEMBL4519317 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468209 | — | Kd | = | 17.9 | nM | 7.75 |
| CHEMBL4526946 | — | Kd | = | 21.4 | nM | 7.67 |
| CHEMBL4565909 | — | Kd | = | 34.2 | nM | 7.47 |
| CHEMBL4566017 | — | Kd | = | 38.3 | nM | 7.42 |
| CHEMBL4452581 | — | Kd | = | 41.2 | nM | 7.38 |
| CHEMBL4558509 | — | Kd | = | 43.9 | nM | 7.36 |
| CHEMBL4436828 | — | Kd | = | 92.5 | nM | 7.03 |
| CHEMBL4453055 | — | Kd | = | 181.6 | nM | 6.74 |
| CHEMBL4519317 | — | Kd | - | — | - |