Assay Detail
Functional
CHEMBL4412027
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Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.49 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437037 | — | — | 1 | 8.22 |
| CHEMBL4474171 | — | — | 1 | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.96 |
| CHEMBL4462385 | — | — | 1 | 7.57 |
| CHEMBL4517935 | — | — | 1 | 7.47 |
| CHEMBL4454712 | — | — | 1 | 6.99 |
| CHEMBL4453018 | — | — | 1 | 6.95 |
| CHEMBL4470691 | — | — | 1 | 6.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437037 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4474171 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4462385 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4517935 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4454712 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4453018 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4470691 | — | IC50 | = | 204.0 | nM | 6.69 |