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Compound Detail

CHEMBL4470691

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C=C(c1ccc2[nH]ccc2c1)c1cc(C)nc2ccccc12

Basic Information

ChEMBL ID CHEMBL4470691
Phase Preclinical
Structure Type MOL
InChI Key PQAXZBZEZIBOMM-UHFFFAOYSA-N
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

284.4
MW (Da)
5.09
ALogP
1
HBA
1
HBD
28.7
PSA (Ų)
0.55
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H16N2
MW 284.36
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -0.63

Activity Summary

IC50 7 meas. best 6.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
K562
CHEMBL385
IC50 6.92 6.92 121.0 1
Unchecked
CHEMBL612545
IC50 6.74 6.74 184.0 1
MDA-MB-231
CHEMBL400
IC50 6.69 6.69 204.0 1
KB
CHEMBL398
IC50 6.43 6.43 372.0 1
HepG2
CHEMBL395
IC50 6.42 6.42 377.0 1
HCT-8
CHEMBL613510
IC50 6.39 6.39 403.0 1
L02
CHEMBL4296457
IC50 6.05 6.05 881.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine