Assay Detail
ADMET
CHEMBL4412029
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Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.94 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.34 |
| CHEMBL4437037 | — | — | 1 | 7.32 |
| CHEMBL4517935 | — | — | 1 | 7.26 |
| CHEMBL4462385 | — | — | 1 | 7.07 |
| CHEMBL4474171 | — | — | 1 | 7.06 |
| CHEMBL4453018 | — | — | 1 | 6.71 |
| CHEMBL4454712 | — | — | 1 | 6.67 |
| CHEMBL4470691 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4437037 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4517935 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4462385 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4474171 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4453018 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL4454712 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL4470691 | — | IC50 | = | 881.0 | nM | 6.05 |