Assay Detail
Functional
CHEMBL4412239
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Antiproliferative activity against p53+/+ human HCT116 cells after 72 hrs by CellTiter 96 aqueous one solution assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The p53 stabilizing agent CP-31398 and multi-kinase inhibitors. Designing, synthesizing and screening of styrylquinazoline series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 4.89 | 5.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1090672 | — | — | 1 | 5.61 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 5.45 |
| CHEMBL4436086 | — | — | 1 | 5.36 |
| CHEMBL4470772 | — | — | 1 | 4.97 |
| CHEMBL4437669 | — | — | 1 | 4.96 |
| CHEMBL4453032 | — | — | 1 | 4.81 |
| CHEMBL4476482 | — | — | 1 | 4.80 |
| CHEMBL186928 | — | — | 1 | 4.73 |
| CHEMBL4459984 | — | — | 1 | 4.66 |
| CHEMBL4553117 | — | — | 1 | 4.66 |
| CHEMBL4571210 | — | — | 1 | 4.64 |
| CHEMBL4459848 | — | — | 1 | 4.63 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.35 |
| CHEMBL1092207 | — | — | 1 | - |
| CHEMBL4583163 | — | — | 1 | - |
| CHEMBL4559299 | — | — | 1 | - |
| CHEMBL4468697 | — | — | 1 | - |
| CHEMBL4470620 | — | — | 1 | - |
| CHEMBL4518551 | — | — | 1 | - |
| CHEMBL4576121 | — | — | 1 | - |
| CHEMBL4445408 | — | — | 1 | - |
| CHEMBL4539405 | — | — | 1 | - |
| CHEMBL4455338 | — | — | 1 | - |
| CHEMBL4458986 | — | — | 1 | - |
| CHEMBL4550950 | — | — | 1 | - |
| CHEMBL4442304 | — | — | 1 | - |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | - |
| CHEMBL4535076 | — | — | 1 | - |
| CHEMBL426161 | AZM-475271 | 2.0 | 1 | - |
| CHEMBL4472770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1090672 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL4436086 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL4470772 | — | IC50 | = | 10770.0 | nM | 4.97 |
| CHEMBL4437669 | — | IC50 | = | 10890.0 | nM | 4.96 |
| CHEMBL4453032 | — | IC50 | = | 15330.0 | nM | 4.81 |
| CHEMBL4476482 | — | IC50 | = | 15940.0 | nM | 4.80 |
| CHEMBL186928 | — | IC50 | = | 18630.0 | nM | 4.73 |
| CHEMBL4459984 | — | IC50 | = | 21690.0 | nM | 4.66 |
| CHEMBL4553117 | — | IC50 | = | 21920.0 | nM | 4.66 |
| CHEMBL4571210 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4459848 | — | IC50 | = | 23280.0 | nM | 4.63 |
| CHEMBL941 | IMATINIB | IC50 | = | 44550.0 | nM | 4.35 |
| CHEMBL4517514 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1092204 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1092207 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4583163 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4559299 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4468697 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4470620 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4518551 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4576121 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4445408 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4539405 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4455338 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4458986 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4550950 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL4442304 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL1289926 | AXITINIB | IC50 | > | 25000.0 | nM | - |
| CHEMBL4535076 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL426161 | AZM-475271 | IC50 | > | 25000.0 | nM | - |
| CHEMBL4472770 | — | IC50 | > | 25000.0 | nM | - |