Assay Detail
Binding
CHEMBL4413387
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Inhibition of OST-tagged DGKalpha (unknown origin) expressed in MDCK cell homogenates using DAG as substrate measured after 5 mins in presence of [gamma-32P]ATP by TLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1494303 | — | — | 1 | 5.37 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | — | 1 | 4.97 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 4.78 |
| CHEMBL259388 | — | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1494303 | — | IC50 | = | 4281.0 | nM | 5.37 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL267777 | RITANSERIN | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL259388 | — | IC50 | = | 19700.0 | nM | 4.71 |