Assay Detail
Binding
CHEMBL4413403
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DGKalpha in human erythrocytes using OAG as substrate preincubated for 1 min followed by OAG addition and measured after 8 mins in presence of [gamma-32P]ATP
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.85 | 5.65 |
| IC50 | 2 | 5.97 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | — | 1 | 6.52 |
| CHEMBL2288168 | COCHLIOQUINONE A | — | 1 | 5.65 |
| CHEMBL2288178 | STEMPHONE | — | 1 | 5.48 |
| CHEMBL259388 | — | — | 1 | 5.42 |
| CHEMBL2268841 | ETHYLENE GLYCOL DIOCTANOATE | — | 1 | 4.24 |
| CHEMBL428593 | GLYCERYL MONOOLEATE | -1.0 | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2288168 | COCHLIOQUINONE A | Ki | = | 2260.0 | nM | 5.65 |
| CHEMBL2288178 | STEMPHONE | Ki | = | 3320.0 | nM | 5.48 |
| CHEMBL259388 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL2268841 | ETHYLENE GLYCOL DIOCTANOATE | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL428593 | GLYCERYL MONOOLEATE | Ki | = | 91000.0 | nM | 4.04 |