Assay Detail
ADMET
CHEMBL4413429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CYP1A2 in presence of NADPH by luciferase reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.76 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4468270 | — | — | 1 | 6.40 |
| CHEMBL4551139 | — | — | 1 | 5.92 |
| CHEMBL4569370 | — | — | 1 | 5.70 |
| CHEMBL405845 | FURAFYLLINE | 2.0 | 1 | 5.64 |
| CHEMBL315874 | — | — | 1 | 5.16 |
| CHEMBL4438726 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4468270 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4551139 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4569370 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL405845 | FURAFYLLINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL315874 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4438726 | — | IC50 | > | 30000.0 | nM | - |