Assay Detail
Binding
CHEMBL4413460
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant iPLA2 assessed as reduction in free FA formation after 30 mins by HPLC-MS analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
85/88 kDa calcium-independent phospholipase A2 (CHEMBL3213) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Substrate-Specific Inhibition Constants for Phospholipase A<sub>2</sub> Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| XI50 | 1 | - | - |
| IC50 | 1 | 7.32 | 7.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89506 | — | — | 2 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89506 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL89506 | — | XI50 | = | 7e-05 | uM | - |