Assay Detail
Functional
CHEMBL4413533
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.15 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4552057 | — | — | 1 | 8.15 |
| CHEMBL4532398 | — | — | 1 | 7.76 |
| CHEMBL4459193 | — | — | 1 | 7.61 |
| CHEMBL4559849 | — | — | 1 | 7.58 |
| CHEMBL4437152 | — | — | 1 | 7.47 |
| CHEMBL4534811 | — | — | 1 | 7.46 |
| CHEMBL4452658 | — | — | 1 | 7.42 |
| CHEMBL4437811 | — | — | 1 | 7.37 |
| CHEMBL4474950 | — | — | 1 | 7.29 |
| CHEMBL4471683 | — | — | 1 | 7.24 |
| CHEMBL4469377 | — | — | 1 | 7.21 |
| CHEMBL4475649 | — | — | 1 | 7.21 |
| CHEMBL4466560 | — | — | 1 | 7.17 |
| CHEMBL4460325 | — | — | 1 | 7.17 |
| CHEMBL4518241 | — | — | 1 | 7.14 |
| CHEMBL4475161 | — | — | 1 | 7.12 |
| CHEMBL4582850 | — | — | 1 | 7.08 |
| CHEMBL4523019 | — | — | 1 | 7.05 |
| CHEMBL4535681 | — | — | 1 | 7.00 |
| CHEMBL4441869 | — | — | 1 | 6.98 |
| CHEMBL4533346 | — | — | 1 | 6.97 |
| CHEMBL4473569 | — | — | 1 | 6.96 |
| CHEMBL4439091 | — | — | 1 | 6.84 |
| CHEMBL4589811 | — | — | 1 | 6.79 |
| CHEMBL4576271 | — | — | 1 | 6.53 |
| CHEMBL4471554 | — | — | 1 | 6.36 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.05 |
| CHEMBL4545617 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552057 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4532398 | — | IC50 | = | 17.2 | nM | 7.76 |
| CHEMBL4459193 | — | IC50 | = | 24.6 | nM | 7.61 |
| CHEMBL4559849 | — | IC50 | = | 26.1 | nM | 7.58 |
| CHEMBL4437152 | — | IC50 | = | 33.9 | nM | 7.47 |
| CHEMBL4534811 | — | IC50 | = | 34.9 | nM | 7.46 |
| CHEMBL4452658 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4437811 | — | IC50 | = | 42.9 | nM | 7.37 |
| CHEMBL4474950 | — | IC50 | = | 51.6 | nM | 7.29 |
| CHEMBL4471683 | — | IC50 | = | 57.2 | nM | 7.24 |
| CHEMBL4469377 | — | IC50 | = | 61.9 | nM | 7.21 |
| CHEMBL4475649 | — | IC50 | = | 61.3 | nM | 7.21 |
| CHEMBL4466560 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4460325 | — | IC50 | = | 66.9 | nM | 7.17 |
| CHEMBL4518241 | — | IC50 | = | 72.8 | nM | 7.14 |
| CHEMBL4475161 | — | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL4582850 | — | IC50 | = | 83.5 | nM | 7.08 |
| CHEMBL4523019 | — | IC50 | = | 89.9 | nM | 7.05 |
| CHEMBL4535681 | — | IC50 | = | 100.1 | nM | 7.00 |
| CHEMBL4441869 | — | IC50 | = | 103.9 | nM | 6.98 |
| CHEMBL4533346 | — | IC50 | = | 106.9 | nM | 6.97 |
| CHEMBL4473569 | — | IC50 | = | 110.9 | nM | 6.96 |
| CHEMBL4439091 | — | IC50 | = | 143.5 | nM | 6.84 |
| CHEMBL4589811 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL4576271 | — | IC50 | = | 296.3 | nM | 6.53 |
| CHEMBL4471554 | — | IC50 | = | 440.7 | nM | 6.36 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 882.5 | nM | 6.05 |
| CHEMBL4545617 | — | IC50 | > | 500.0 | nM | - |