Assay Detail
Binding
CHEMBL4413541
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length HDAC3 (unknown origin) using Ac-peptide-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.24 | 8.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532398 | — | — | 1 | 8.83 |
| CHEMBL4552057 | — | — | 1 | 8.38 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532398 | — | IC50 | = | 1.47 | nM | 8.83 |
| CHEMBL4552057 | — | IC50 | = | 4.21 | nM | 8.38 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 30.0 | nM | 7.52 |