Assay Detail
Binding
CHEMBL4413709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assay
22
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Discovery of a Series of 2'-α-Fluoro,2'-β-bromo-ribonucleosides and Their Phosphoramidate Prodrugs as Potent Pan-Genotypic Inhibitors of Hepatitis C Virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 6.23 | 7.62 |
| EC90 | 11 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4455349 | — | — | 2 | 7.62 |
| CHEMBL1259059 | SOFOSBUVIR | 4.0 | 2 | 7.47 |
| CHEMBL4462484 | — | — | 2 | 6.30 |
| CHEMBL4532929 | — | — | 2 | 6.22 |
| CHEMBL4540766 | — | — | 2 | 6.22 |
| CHEMBL4469773 | — | — | 2 | 6.16 |
| CHEMBL438605 | — | — | 2 | 5.55 |
| CHEMBL4474735 | — | — | 2 | 5.40 |
| CHEMBL4578489 | — | — | 2 | 5.15 |
| CHEMBL4545962 | — | — | 2 | - |
| CHEMBL4454584 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4455349 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1259059 | SOFOSBUVIR | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4462484 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4532929 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4540766 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4469773 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL438605 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4474735 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4578489 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4462484 | — | EC90 | = | 0.9 | uM | - |
| CHEMBL4474735 | — | EC90 | = | 9.5 | uM | - |
| CHEMBL4532929 | — | EC90 | = | 1.8 | uM | - |
| CHEMBL4545962 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4545962 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4578489 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4454584 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4540766 | — | EC90 | = | 1.8 | uM | - |
| CHEMBL4469773 | — | EC90 | = | 0.53 | uM | - |
| CHEMBL4455349 | — | EC90 | = | 0.074 | uM | - |
| CHEMBL438605 | — | EC90 | = | 9.9 | uM | - |
| CHEMBL1259059 | SOFOSBUVIR | EC90 | = | 0.15 | uM | - |
| CHEMBL4454584 | — | EC90 | > | 10.0 | uM | - |