Assay Detail
Binding
CHEMBL4414331
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Activation of human Gal4-fused RXRalpha LBD transfected in HEK293T after 14 to 16 hrs by dual-glo luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.23 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558880 | — | — | 1 | 7.03 |
| CHEMBL4518775 | — | — | 1 | 6.02 |
| CHEMBL4575123 | — | — | 1 | 5.85 |
| CHEMBL459521 | — | — | 1 | 5.82 |
| CHEMBL4458208 | — | — | 1 | 5.68 |
| CHEMBL44078 | — | — | 1 | 5.55 |
| CHEMBL42489 | — | — | 1 | 5.33 |
| CHEMBL4443400 | — | — | 1 | 5.21 |
| CHEMBL4439891 | — | — | 1 | 5.17 |
| CHEMBL4533202 | — | — | 1 | 5.14 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.04 |
| CHEMBL4459701 | — | — | 1 | 5.02 |
| CHEMBL4465004 | — | — | 1 | 5.01 |
| CHEMBL4548975 | — | — | 1 | 5.00 |
| CHEMBL512563 | — | — | 1 | 4.89 |
| CHEMBL4439052 | — | — | 1 | 4.70 |
| CHEMBL4514313 | — | — | 1 | 4.60 |
| CHEMBL454691 | — | — | 1 | 4.57 |
| CHEMBL4556277 | — | — | 1 | 4.52 |
| CHEMBL4471255 | — | — | 1 | 4.44 |
| CHEMBL274797 | — | — | 1 | - |
| CHEMBL461409 | — | — | 1 | - |
| CHEMBL459972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558880 | — | EC50 | = | 93.0 | nM | 7.03 |
| CHEMBL4518775 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4575123 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL459521 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4458208 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL44078 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL42489 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4443400 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4439891 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4533202 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL4459701 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4465004 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4548975 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL512563 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4439052 | — | EC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4514313 | — | EC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL454691 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4556277 | — | EC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4471255 | — | EC50 | = | 36400.0 | nM | 4.44 |
| CHEMBL274797 | — | EC50 | - | — | - | |
| CHEMBL461409 | — | EC50 | - | — | - | |
| CHEMBL459972 | — | EC50 | - | — | - |