Compound Detail
CHEMBL459521
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Basic Information
| ChEMBL ID | CHEMBL459521 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OGXCCWPSBAOWEN-UHFFFAOYSA-N |
6
Targets
6
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
335.8
MW (Da)
3.54
ALogP
5
HBA
2
HBD
75.1
PSA (Ų)
0.49
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 5 meas. best 5.82
IC50 1 meas. best 5.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha CHEMBL2061 | EC50 | 5.82 | 5.82 | 1500.0 | 1 |
| Retinoic acid receptor RXR-beta CHEMBL1870 | EC50 | 5.51 | 5.51 | 3100.0 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL215 | IC50 | 5.41 | 5.41 | 3900.0 | 1 |
| Retinoic acid receptor RXR-gamma CHEMBL2004 | EC50 | 5.25 | 5.25 | 5600.0 | 1 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | EC50 | 4.8 | 4.8 | 16000.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 4.42 | 4.42 | 38000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Retinoic acid receptor RXR-alpha | EC50 | = | 1500.0 | nM | 5.82 | Activation of human Gal4-fused RXRalpha LBD transfected in HEK293T after 14 to 1... | 30702885 |
| Retinoic acid receptor RXR-beta | EC50 | = | 3100.0 | nM | 5.51 | Activation of human Gal4-fused RXRbeta LBD transfected in HEK293T after 14 to 16... | 30702885 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 3900.0 | nM | 5.41 | Inhibition of 5-lipoxygenase in human intact polymorphonuclear leukocytes assess... | 18710209 |
| Retinoic acid receptor RXR-gamma | EC50 | = | 5600.0 | nM | 5.25 | Activation of human Gal4-fused RXRgamma LBD transfected in HEK293T after 14 to 1... | 30702885 |
| Peroxisome proliferator-activated receptor alpha | EC50 | = | 16000.0 | nM | 4.8 | Activation of human Gal4-fused PPARalpha LBD transfected in HEK293T after 14 to ... | 30702885 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 38000.0 | nM | 4.42 | Activation of human Gal4-fused PPARgamma LBD transfected in HEK293T after 14 to ... | 30702885 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18710209 | 10.1021/jm800588x | Polyunsaturated fatty acid 5-lipoxygenase | 3 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Retinoic acid receptor RXR-alpha | 2 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Retinoic acid receptor RXR-beta | 2 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Retinoic acid receptor RXR-gamma | 2 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Peroxisome proliferator-activated receptor alpha | 2 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Peroxisome proliferator-activated receptor gamma | 2 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | Peroxisome proliferator-activated receptor delta | 1 |
| 30702885 | 10.1021/acs.jmedchem.8b01848 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine