Assay Detail
Functional
CHEMBL4414683
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Vasodilating activity in Wistar rat aortic rings assessed as reduction in KCl-induced contractions
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.09 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.54 |
| CHEMBL236789 | MONASTROL | — | 1 | 5.92 |
| CHEMBL4520875 | — | — | 1 | 4.92 |
| CHEMBL86889 | — | — | 1 | 4.80 |
| CHEMBL4580791 | — | — | 1 | 4.44 |
| CHEMBL4585154 | — | — | 1 | 4.43 |
| CHEMBL4458540 | — | — | 1 | 4.42 |
| CHEMBL4203316 | — | — | 1 | 4.28 |
| CHEMBL2013079 | — | — | 1 | 4.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL236789 | MONASTROL | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4520875 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL86889 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4580791 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4585154 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4458540 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL4203316 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL2013079 | — | IC50 | = | 91000.0 | nM | 4.04 |