Assay Detail
Functional
CHEMBL4414752
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Cytotoxicity against VHL-positive human RCC4/VHL cells assessed as reduction in cell viability incubated for 4 days by XTT assay
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RCC4/VHL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.68 | 5.28 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL565269 | — | — | 1 | 5.28 |
| CHEMBL4579523 | — | — | 1 | 4.91 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.54 |
| CHEMBL131678 | — | — | 2 | 4.00 |
| CHEMBL4515200 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL565269 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4579523 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL131678 | — | IC50 | = | 99600.0 | nM | 4.00 |
| CHEMBL4515200 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL131678 | — | Activity | - | — | - |