Assay Detail
Binding
CHEMBL4414786
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH1 domain (unknown origin)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.50 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4561663 | — | — | 1 | 7.82 |
| CHEMBL4530719 | — | — | 1 | 7.38 |
| CHEMBL4444178 | — | — | 1 | 4.30 |
| CHEMBL4537678 | — | — | 1 | - |
| CHEMBL4559521 | — | — | 1 | - |
| CHEMBL4466720 | — | — | 1 | - |
| CHEMBL4516272 | — | — | 1 | - |
| CHEMBL4526283 | — | — | 1 | - |
| CHEMBL4444169 | — | — | 1 | - |
| CHEMBL4440718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4561663 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4530719 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4444178 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL4537678 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4559521 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4466720 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4516272 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4526283 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4444169 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4440718 | — | IC50 | > | 50000.0 | nM | - |