Assay Detail
ADMET
CHEMBL4414792
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Inhibition of JAK1/JAK2 (unknown origin) in GM-CSF stimulated cells by cell based assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.63 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4561663 | — | — | 1 | 6.68 |
| CHEMBL4530719 | — | — | 1 | 6.58 |
| CHEMBL4537678 | — | — | 1 | - |
| CHEMBL4559521 | — | — | 1 | - |
| CHEMBL4466720 | — | — | 1 | - |
| CHEMBL4516272 | — | — | 1 | - |
| CHEMBL4526283 | — | — | 1 | - |
| CHEMBL4444169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4561663 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4530719 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4537678 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4559521 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4466720 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4516272 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4526283 | — | IC50 | > | 12500.0 | nM | - |
| CHEMBL4444169 | — | IC50 | > | 12500.0 | nM | - |