Assay Detail
ADMET
CHEMBL4414830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cKIT (unknown origin)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.43 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4526283 | — | — | 1 | 7.00 |
| CHEMBL4544320 | — | — | 1 | 6.20 |
| CHEMBL4444606 | — | — | 1 | 6.08 |
| CHEMBL4548200 | — | — | 1 | - |
| CHEMBL4472802 | — | — | 1 | - |
| CHEMBL4453545 | — | — | 1 | - |
| CHEMBL4438202 | — | — | 1 | - |
| CHEMBL4542289 | — | — | 1 | - |
| CHEMBL4531793 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4526283 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4544320 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4444606 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4548200 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4472802 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4453545 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4438202 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4542289 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL4531793 | — | IC50 | > | 2000.0 | nM | - |