Assay Detail
Binding
CHEMBL4414854
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TYK2 JH2 (unknown origin) by morrison titration assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Non-receptor tyrosine-protein kinase TYK2 (CHEMBL3553) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of <i>N</i>-Methyl Nicotinamide and <i>N</i>-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 9.82 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4561663 | — | — | 1 | 10.22 |
| CHEMBL4440718 | — | — | 1 | 10.15 |
| CHEMBL4444178 | — | — | 1 | 9.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4561663 | — | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL4440718 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL4444178 | — | Ki | = | 0.8 | nM | 9.10 |