Assay Detail
Functional
CHEMBL4414912
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human OCI-LY10 cells after 6 days by Celltiter-glo luminescent cell viability assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-Ly10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 9.49 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 9.52 |
| CHEMBL3936761 | ZANUBRUTINIB | 4.0 | 1 | 9.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL3936761 | ZANUBRUTINIB | IC50 | = | 0.35 | nM | 9.46 |