Assay Detail
Functional
CHEMBL4415072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Dengue virus 4 D4MY01-22713 infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay
58
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-<i>b</i>]pyridine-7,3'-indoline]-2',5(3<i>H</i>)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 58 | 5.29 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435899 | — | — | 1 | 5.52 |
| CHEMBL4554332 | — | — | 1 | 5.50 |
| CHEMBL4593413 | — | — | 1 | 5.46 |
| CHEMBL4555033 | — | — | 1 | 5.41 |
| CHEMBL4568250 | — | — | 1 | 5.36 |
| CHEMBL4591166 | — | — | 1 | 5.31 |
| CHEMBL4452557 | — | — | 1 | 5.29 |
| CHEMBL4434650 | — | — | 1 | 5.21 |
| CHEMBL4476758 | — | — | 1 | 5.19 |
| CHEMBL4465052 | — | — | 1 | 5.14 |
| CHEMBL4447821 | — | — | 1 | 5.13 |
| CHEMBL4470681 | — | — | 1 | 5.00 |
| CHEMBL4459642 | — | — | 1 | - |
| CHEMBL4470346 | — | — | 1 | - |
| CHEMBL4548394 | — | — | 1 | - |
| CHEMBL4436766 | — | — | 1 | - |
| CHEMBL4455078 | — | — | 1 | - |
| CHEMBL4459375 | — | — | 1 | - |
| CHEMBL4467064 | — | — | 1 | - |
| CHEMBL4475296 | — | — | 1 | - |
| CHEMBL4538323 | — | — | 1 | - |
| CHEMBL4447223 | — | — | 1 | - |
| CHEMBL4452845 | — | — | 1 | - |
| CHEMBL4571778 | — | — | 1 | - |
| CHEMBL4521186 | — | — | 1 | - |
| CHEMBL4471937 | — | — | 1 | - |
| CHEMBL4572212 | — | — | 1 | - |
| CHEMBL4536890 | — | — | 1 | - |
| CHEMBL4454595 | — | — | 1 | - |
| CHEMBL4538647 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435899 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4554332 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4593413 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4555033 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4568250 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4591166 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4452557 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4434650 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4476758 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4465052 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4447821 | — | EC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4470681 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4473559 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4565921 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4574618 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4513651 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4451009 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4449100 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4483405 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4586370 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4470440 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4548448 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4458661 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4579860 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4446551 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4521110 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4437627 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4576872 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4519498 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4440652 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4475139 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4538323 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4538647 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4454595 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4536890 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4572212 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4471937 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4521186 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4571778 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4452845 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4447223 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4472422 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4475296 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4467064 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4459375 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4455078 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4436766 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4548394 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4470346 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL4459642 | — | EC50 | > | 5000.0 | nM | - |