Assay Detail
Binding
CHEMBL4415258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of hexa-His-tagged human soluble epoxide hydrolase N-terminal phosphatase domain expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before FDP substrate addition by fluorescence based assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.73 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4445524 | — | — | 1 | 7.24 |
| CHEMBL4577226 | — | — | 1 | 6.92 |
| CHEMBL4534713 | — | — | 1 | 6.92 |
| CHEMBL4471300 | — | — | 1 | 6.92 |
| CHEMBL4590804 | — | — | 1 | 6.85 |
| CHEMBL4572648 | — | — | 1 | 6.82 |
| CHEMBL4440023 | — | — | 1 | 6.64 |
| CHEMBL4438961 | — | — | 1 | 6.55 |
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.54 |
| CHEMBL4452835 | — | — | 1 | 6.51 |
| CHEMBL4463708 | — | — | 1 | 6.51 |
| CHEMBL4587758 | — | — | 1 | 6.51 |
| CHEMBL4445500 | — | — | 1 | 6.39 |
| CHEMBL4472947 | — | — | 1 | 6.29 |
| CHEMBL1555989 | — | — | 1 | 6.26 |
| CHEMBL4452744 | — | — | 1 | 5.70 |
| CHEMBL23393 | SODIUM LAURYL SULFATE | 3.0 | 1 | 5.64 |
| CHEMBL4435798 | — | — | 1 | 5.52 |
| CHEMBL4515740 | — | — | 1 | 5.52 |
| CHEMBL4455443 | — | — | 1 | 5.40 |
| CHEMBL1071 | OXAPROZIN | 4.0 | 1 | 5.30 |
| CHEMBL4473552 | — | — | 1 | 5.16 |
| CHEMBL4446467 | — | — | 1 | 5.05 |
| CHEMBL4534394 | — | — | 1 | 5.05 |
| CHEMBL4572075 | — | — | 1 | 5.00 |
| CHEMBL4463847 | — | — | 1 | 4.92 |
| CHEMBL4539572 | — | — | 1 | 4.82 |
| CHEMBL4568999 | — | — | 1 | 4.77 |
| CHEMBL4447972 | — | — | 1 | 4.75 |
| CHEMBL4460598 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4445524 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4577226 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4471300 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4534713 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4590804 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4572648 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4440023 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4438961 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL51085 | EBSELEN | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4452835 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4463708 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4587758 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4445500 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4472947 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL1555989 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4452744 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL23393 | SODIUM LAURYL SULFATE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4435798 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4515740 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4455443 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1071 | OXAPROZIN | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4473552 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4446467 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4534394 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4572075 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4463847 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4539572 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4568999 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4447972 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4460598 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4438388 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4439422 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4585595 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL4526014 | — | IC50 | = | 44000.0 | nM | 4.36 |
| CHEMBL4469839 | — | IC50 | > | 50000.0 | nM | - |