Assay Detail
Binding
CHEMBL4415280
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Inhibition of hexa-His-tagged human soluble epoxide hydrolase C-terminal hydrolase domain expressed in Escherichia coli BL21(DE3) pre-incubated for 30 mins before DiFMUP substrate addition by fluorescence based assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.94 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | 3.0 | 1 | 6.96 |
| CHEMBL4445524 | — | — | 1 | 4.92 |
| CHEMBL23393 | SODIUM LAURYL SULFATE | 3.0 | 1 | - |
| CHEMBL1555989 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51085 | EBSELEN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4445524 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL23393 | SODIUM LAURYL SULFATE | IC50 | = | 101000.0 | nM | - |
| CHEMBL1555989 | — | IC50 | > | 300000.0 | nM | - |