Assay Detail
Functional
CHEMBL4415801
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Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of <i>Alangium salviifolium</i> and Their Cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.82 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4541615 | — | — | 1 | 8.00 |
| CHEMBL4212545 | — | — | 1 | 7.00 |
| CHEMBL4556326 | — | — | 1 | 5.92 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | — | 1 | 5.89 |
| CHEMBL4568442 | — | — | 1 | 5.28 |
| CHEMBL255708 | CEPHAELINE | — | 1 | 5.12 |
| CHEMBL4449277 | — | — | 1 | 5.09 |
| CHEMBL4517864 | — | — | 1 | 5.04 |
| CHEMBL486005 | ISOCEPHAELINE | — | 1 | 5.03 |
| CHEMBL4514929 | — | — | 1 | - |
| CHEMBL518568 | TUBULOSINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4541615 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4212545 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4556326 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4568442 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL255708 | CEPHAELINE | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4449277 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4517864 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL486005 | ISOCEPHAELINE | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4514929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL518568 | TUBULOSINE | IC50 | > | 10000.0 | nM | - |