Compound Detail
CHEMBL518568
TUBULOSINE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2c1[nH]c1ccc(O)cc21
Basic Information
| ChEMBL ID | CHEMBL518568 |
| Name | TUBULOSINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JRVWIILYWSBUMC-PRUVNFMMSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
475.6
MW (Da)
5.11
ALogP
5
HBA
3
HBD
69.8
PSA (Ų)
0.48
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.4
Target Activity Profile
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| SK-OV-3 | IC50 | = | 400.0 | nM | 6.4 | Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability i... | 31513408 |
| A549 | IC50 | = | 2100.0 | nM | 5.68 | Cytotoxicity against human A549 cells assessed as reduction in cell viability in... | 31513408 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10514334 | 10.1021/np990255u | KB | 3 |
| 1982768 | 10.1021/np50070a041 | NON-PROTEIN TARGET | 2 |
| 18157122 | 10.1038/nchembio.2007.59 | Janus Kinase (JAK) | 2 |
| 10514334 | 10.1021/np990255u | NON-PROTEIN TARGET | 1 |
| 31513408 | 10.1021/acs.jnatprod.9b00670 | SK-OV-3 | 1 |
| 18157122 | 10.1038/nchembio.2007.59 | MAP kinase p38 | 1 |
| 10514334 | 10.1021/np990255u | M109 | 1 |
| 10514334 | 10.1021/np990255u | SK-N-SH | 1 |
| 10514334 | 10.1021/np990255u | SW626 | 1 |
| 10514334 | 10.1021/np990255u | LNCaP | 1 |
| 10514334 | 10.1021/np990255u | Col2 | 1 |
| 10514334 | 10.1021/np990255u | Lu1 | 1 |
| 1982768 | 10.1021/np50070a041 | Artemia | 1 |
| 10514334 | 10.1021/np990255u | P388 | 1 |
| 10514334 | 10.1021/np990255u | L1210 | 1 |
| 1710653 | 10.1021/np50073a012 | Human immunodeficiency virus type 1 reverse transcriptase | 1 |
| 1982768 | 10.1021/np50070a041 | Unchecked | 1 |
| 1982768 | 10.1021/np50070a041 | HT-29 | 1 |
| 1982768 | 10.1021/np50070a041 | MCF7 | 1 |
| 1982768 | 10.1021/np50070a041 | A549 | 1 |
Data from ChEMBL 36 via Core Engine