Assay Detail
Functional
CHEMBL4415802
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Cytotoxicity against human SKOV3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-OV-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Octahydro-Protoberberine and Protoemetine-Type Alkaloids from the Stems of <i>Alangium salviifolium</i> and Their Cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.30 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4212545 | — | — | 1 | 8.52 |
| CHEMBL4541615 | — | — | 1 | 7.22 |
| CHEMBL4556326 | — | — | 1 | 7.00 |
| CHEMBL255708 | CEPHAELINE | — | 1 | 7.00 |
| CHEMBL4449277 | — | — | 1 | 6.70 |
| CHEMBL518568 | TUBULOSINE | — | 1 | 6.40 |
| CHEMBL4568442 | — | — | 1 | 5.44 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | — | 1 | 5.43 |
| CHEMBL486005 | ISOCEPHAELINE | — | 1 | 5.41 |
| CHEMBL4514929 | — | — | 1 | 5.28 |
| CHEMBL4517864 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4212545 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4541615 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4556326 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL255708 | CEPHAELINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4449277 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL518568 | TUBULOSINE | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4568442 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL486005 | ISOCEPHAELINE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4514929 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4517864 | — | IC50 | = | 13900.0 | nM | 4.86 |