Assay Detail
Binding
CHEMBL4416031
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal 6x-His-tagged recombinant human cIAP1-BIR3 (258 to 363 residues) expressed in Escherichia coli incubated for 2 hrs without 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Baculoviral IAP repeat-containing protein 2 (CHEMBL5462) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.54 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.73 |
| CHEMBL4437401 | — | — | 1 | 7.62 |
| CHEMBL4581366 | — | — | 1 | 7.60 |
| CHEMBL2158051 | XEVINAPANT | 3.0 | 1 | 7.47 |
| CHEMBL4552412 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2431768 | LCL-161 | IC50 | = | 18.6 | nM | 7.73 |
| CHEMBL4437401 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4581366 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL2158051 | XEVINAPANT | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4552412 | — | IC50 | = | 50.0 | nM | 7.30 |