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Assay Detail

CHEMBL4416174

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against mouse L929 cells assessed as reduction in viability by dual luciferase reporter gene assay
ChEMBL ↗
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Mus musculus
Cell Type L929
Confidence 1 — Organism
Curated By Autocuration

Target

L929 (CHEMBL612267) ↗
Type CELL-LINE
Organism Mus musculus

Publication

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against <i>Plasmodium falciparum</i> Malaria Parasites.
Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA.
J Med Chem (2019) 62 : 9217 -9235
PubMed 31566384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 57 4.94 5.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4519443 — — 1 5.92
CHEMBL4451783 — — 1 5.80
CHEMBL4459320 — — 1 5.75
CHEMBL4513311 — — 1 5.68
CHEMBL4593717 — — 1 5.66
CHEMBL4572858 — — 1 5.64
CHEMBL4585607 — — 1 5.60
CHEMBL4438004 — — 1 5.60
CHEMBL4566588 — — 1 5.55
CHEMBL4446015 — — 1 5.50
CHEMBL4546641 — — 1 5.50
CHEMBL4531226 — — 1 5.48
CHEMBL4455587 — — 1 5.42
CHEMBL4531058 — — 1 5.42
CHEMBL4591417 — — 1 5.40
CHEMBL4449947 — — 1 5.37
CHEMBL4444451 — — 1 5.36
CHEMBL4473609 — — 1 5.30
CHEMBL4288103 — — 1 5.29
CHEMBL4469667 — — 1 5.29
CHEMBL4585479 — — 1 5.28
CHEMBL4572065 — — 1 5.27
CHEMBL4446024 — — 1 5.21
CHEMBL4464676 — — 1 5.19
CHEMBL4459919 — — 1 5.11
CHEMBL4453994 — — 1 5.05
CHEMBL4441206 — — 1 4.92
CHEMBL4444869 — — 1 4.89
CHEMBL4471859 — — 1 4.86
CHEMBL4436765 — — 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4519443 — EC50 = 1200.0 nM 5.92
CHEMBL4451783 — EC50 = 1600.0 nM 5.80
CHEMBL4459320 — EC50 = 1800.0 nM 5.75
CHEMBL4513311 — EC50 = 2100.0 nM 5.68
CHEMBL4593717 — EC50 = 2200.0 nM 5.66
CHEMBL4572858 — EC50 = 2300.0 nM 5.64
CHEMBL4585607 — EC50 = 2500.0 nM 5.60
CHEMBL4438004 — EC50 = 2500.0 nM 5.60
CHEMBL4566588 — EC50 = 2800.0 nM 5.55
CHEMBL4446015 — EC50 = 3200.0 nM 5.50
CHEMBL4546641 — EC50 = 3200.0 nM 5.50
CHEMBL4531226 — EC50 = 3300.0 nM 5.48
CHEMBL4455587 — EC50 = 3800.0 nM 5.42
CHEMBL4531058 — EC50 = 3800.0 nM 5.42
CHEMBL4591417 — EC50 = 4000.0 nM 5.40
CHEMBL4449947 — EC50 = 4300.0 nM 5.37
CHEMBL4444451 — EC50 = 4400.0 nM 5.36
CHEMBL4473609 — EC50 = 5000.0 nM 5.30
CHEMBL4288103 — EC50 = 5100.0 nM 5.29
CHEMBL4469667 — EC50 = 5100.0 nM 5.29
CHEMBL4585479 — EC50 = 5200.0 nM 5.28
CHEMBL4572065 — EC50 = 5400.0 nM 5.27
CHEMBL4446024 — EC50 = 6200.0 nM 5.21
CHEMBL4464676 — EC50 = 6500.0 nM 5.19
CHEMBL4459919 — EC50 = 7800.0 nM 5.11
CHEMBL4453994 — EC50 = 8900.0 nM 5.05
CHEMBL4441206 — EC50 = 12000.0 nM 4.92
CHEMBL4444869 — EC50 = 12900.0 nM 4.89
CHEMBL4471859 — EC50 = 13800.0 nM 4.86
CHEMBL4436765 — EC50 = 15100.0 nM 4.82
CHEMBL4461850 — EC50 = 15100.0 nM 4.82
CHEMBL4586918 — EC50 = 15500.0 nM 4.81
CHEMBL4551036 — EC50 = 15500.0 nM 4.81
CHEMBL4286841 — EC50 = 17000.0 nM 4.77
CHEMBL4565096 — EC50 = 17000.0 nM 4.77
CHEMBL4548154 — EC50 = 18600.0 nM 4.73
CHEMBL4462111 — EC50 = 19500.0 nM 4.71
CHEMBL4566303 — EC50 = 20000.0 nM 4.70
CHEMBL4516715 — EC50 = 21400.0 nM 4.67
CHEMBL4567664 — EC50 = 25700.0 nM 4.59
CHEMBL4437350 — EC50 = 25700.0 nM 4.59
CHEMBL4552534 — EC50 = 27500.0 nM 4.56
CHEMBL4454838 — EC50 = 33900.0 nM 4.47
CHEMBL4465850 — EC50 = 37200.0 nM 4.43
CHEMBL4448543 — EC50 = 38000.0 nM 4.42
CHEMBL4461043 — EC50 = 43700.0 nM 4.36
CHEMBL4572752 — EC50 = 44700.0 nM 4.35
CHEMBL4586441 — EC50 = 55000.0 nM 4.26
CHEMBL4534387 — EC50 = 61700.0 nM 4.21
CHEMBL4536120 — EC50 = 72400.0 nM 4.14