Assay Detail
Functional
CHEMBL4416376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Allosteric modulator activity at CB1 receptor in mouse cerebellar membranes assessed as suppression of 100 nM CP55,940-induced [35S]GTPgammaS binding incubated for 60 mins by scintillation counting method
40
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Cerebellum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 6.34 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527602 | — | — | 1 | 7.20 |
| CHEMBL4584483 | — | — | 2 | 6.96 |
| CHEMBL4590582 | — | — | 2 | 6.86 |
| CHEMBL4452850 | — | — | 2 | 6.76 |
| CHEMBL4581327 | — | — | 2 | 6.69 |
| CHEMBL3341861 | — | — | 2 | 6.54 |
| CHEMBL4464917 | — | — | 2 | 6.44 |
| CHEMBL4528445 | — | — | 1 | 6.11 |
| CHEMBL4513477 | — | — | 2 | 5.52 |
| CHEMBL4474515 | — | — | 2 | 5.48 |
| CHEMBL4450625 | — | — | 2 | 5.46 |
| CHEMBL4542852 | — | — | 1 | - |
| CHEMBL4591294 | — | — | 1 | - |
| CHEMBL4443540 | — | — | 1 | - |
| CHEMBL4468436 | — | — | 1 | - |
| CHEMBL4475934 | — | — | 1 | - |
| CHEMBL4457227 | — | — | 1 | - |
| CHEMBL4572697 | — | — | 1 | - |
| CHEMBL4443032 | — | — | 1 | - |
| CHEMBL4544453 | — | — | 1 | - |
| CHEMBL4577814 | — | — | 1 | - |
| CHEMBL4450873 | — | — | 1 | - |
| CHEMBL4472252 | — | — | 1 | - |
| CHEMBL4577767 | — | — | 1 | - |
| CHEMBL4554290 | — | — | 1 | - |
| CHEMBL4442623 | — | — | 1 | - |
| CHEMBL4542455 | — | — | 1 | - |
| CHEMBL4438047 | — | — | 1 | - |
| CHEMBL4580323 | — | — | 1 | - |
| CHEMBL4565127 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527602 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4584483 | — | IC50 | = | 109.65 | nM | 6.96 |
| CHEMBL4584483 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4590582 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL4590582 | — | IC50 | = | 138.04 | nM | 6.86 |
| CHEMBL4452850 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL4452850 | — | IC50 | = | 173.78 | nM | 6.76 |
| CHEMBL4581327 | — | IC50 | = | 204.17 | nM | 6.69 |
| CHEMBL4581327 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL3341861 | — | IC50 | = | 288.4 | nM | 6.54 |
| CHEMBL3341861 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL4464917 | — | IC50 | = | 363.08 | nM | 6.44 |
| CHEMBL4464917 | — | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL4528445 | — | IC50 | = | 776.0 | nM | 6.11 |
| CHEMBL4513477 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL4513477 | — | IC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL4474515 | — | IC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL4474515 | — | IC50 | = | 3311.0 | nM | 5.48 |
| CHEMBL4450625 | — | IC50 | = | 3467.37 | nM | 5.46 |
| CHEMBL4450625 | — | IC50 | = | 3467.0 | nM | 5.46 |
| CHEMBL4450873 | — | IC50 | - | — | - | |
| CHEMBL4544453 | — | IC50 | - | — | - | |
| CHEMBL4472252 | — | IC50 | - | — | - | |
| CHEMBL4577767 | — | IC50 | - | — | - | |
| CHEMBL4554290 | — | IC50 | - | — | - | |
| CHEMBL4442623 | — | IC50 | - | — | - | |
| CHEMBL4572697 | — | IC50 | - | — | - | |
| CHEMBL4475934 | — | IC50 | - | — | - | |
| CHEMBL4438047 | — | IC50 | - | — | - | |
| CHEMBL4565127 | — | IC50 | - | — | - | |
| CHEMBL4468436 | — | IC50 | - | — | - | |
| CHEMBL4443540 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4591294 | — | IC50 | - | — | - | |
| CHEMBL4542852 | — | IC50 | - | — | - | |
| CHEMBL4577814 | — | IC50 | - | — | - | |
| CHEMBL4539271 | — | IC50 | - | — | - | |
| CHEMBL4457227 | — | IC50 | - | — | - | |
| CHEMBL4443032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4542455 | — | IC50 | - | — | - | |
| CHEMBL4580323 | — | IC50 | - | — | - |