Assay Detail
ADMET
CHEMBL4416476
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Cytotoxicity against CHOK1 cells assessed as reduction in ATP levels incubated for 24 hrs by ATPlite luminescence assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cricetulus griseus |
| Cell Type | CHO-K1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.79 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4448906 | — | — | 1 | 5.40 |
| CHEMBL4469844 | — | — | 1 | 5.37 |
| CHEMBL4450301 | — | — | 1 | 5.11 |
| CHEMBL4536396 | — | — | 1 | 5.11 |
| CHEMBL4471599 | — | — | 1 | 5.10 |
| CHEMBL4549136 | — | — | 1 | 4.80 |
| CHEMBL4574559 | — | — | 1 | 4.77 |
| CHEMBL4571980 | — | — | 1 | 4.64 |
| CHEMBL4460058 | — | — | 1 | 4.48 |
| CHEMBL4482927 | — | — | 1 | 4.44 |
| CHEMBL4536419 | — | — | 1 | 4.29 |
| CHEMBL4467200 | — | — | 1 | 4.00 |
| CHEMBL4558494 | — | — | 1 | - |
| CHEMBL4526498 | — | — | 1 | - |
| CHEMBL4556988 | — | — | 1 | - |
| CHEMBL4458055 | — | — | 1 | - |
| CHEMBL4517586 | — | — | 1 | - |
| CHEMBL4550310 | — | — | 1 | - |
| CHEMBL4443416 | — | — | 1 | - |
| CHEMBL4463007 | — | — | 1 | - |
| CHEMBL4587709 | — | — | 1 | - |
| CHEMBL4526485 | — | — | 1 | - |
| CHEMBL4463215 | — | — | 1 | - |
| CHEMBL4520559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4448906 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4469844 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4450301 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4536396 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4471599 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL4549136 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4574559 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4571980 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL4460058 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL4482927 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4536419 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL4467200 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4558494 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4526498 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4556988 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4458055 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4517586 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4550310 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4443416 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4463007 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4587709 | — | IC50 | - | — | - | |
| CHEMBL4526485 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4463215 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4520559 | — | IC50 | - | — | - |