Compound Detail
CHEMBL4536396
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4536396 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ADCLIGYIOGFSIW-SNVBAGLBSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
393.4
MW (Da)
2.72
ALogP
7
HBA
1
HBD
93.8
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 CHEMBL2971 | IC50 | 9.52 | 9.52 | 0.3 | 1 |
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Tyrosine-protein kinase JAK1 CHEMBL2835 | IC50 | 8.26 | 8.26 | 5.5 | 1 |
| CHO-K1 CHEMBL614031 | IC50 | 5.11 | 5.11 | 7700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK2 | IC50 | = | 0.3 | nM | 9.52 | Inhibition of recombinant human N-terminal His-tagged JAK2 (826 to 1132 residues... | 31609613 |
| Tyrosine-protein kinase JAK3 | IC50 | = | 3.0 | nM | 8.52 | Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues... | 31609613 |
| Tyrosine-protein kinase JAK1 | IC50 | = | 5.5 | nM | 8.26 | Inhibition of recombinant human GST-tagged JAK1 (866 to 1154 residues) expressed... | 31609613 |
| CHO-K1 | IC50 | = | 7700.0 | nM | 5.11 | Cytotoxicity against CHOK1 cells assessed as reduction in ATP levels incubated f... | 31609613 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31609613 | 10.1021/acs.jmedchem.9b00533 | Tyrosine-protein kinase JAK3 | 1 |
| 31609613 | 10.1021/acs.jmedchem.9b00533 | Tyrosine-protein kinase JAK2 | 1 |
| 31609613 | 10.1021/acs.jmedchem.9b00533 | Tyrosine-protein kinase JAK1 | 1 |
| 31609613 | 10.1021/acs.jmedchem.9b00533 | CHO-K1 | 1 |
Data from ChEMBL 36 via Core Engine