Assay Detail
Binding
CHEMBL4416473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal His-tagged JAK3 (795 to 1124 residues) expressed in Sf1 cells using PolyGT-Biotin as substrate measured after 3 to 20 hrs by HTRF assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 7.96 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4526485 | — | — | 1 | 9.15 |
| CHEMBL4471599 | — | — | 1 | 9.00 |
| CHEMBL4482927 | — | — | 1 | 8.96 |
| CHEMBL4526498 | — | — | 1 | 8.96 |
| CHEMBL4443416 | — | — | 1 | 8.85 |
| CHEMBL4460058 | — | — | 1 | 8.85 |
| CHEMBL3393066 | VS-5584 | 1.0 | 1 | 8.77 |
| CHEMBL4536419 | — | — | 1 | 8.62 |
| CHEMBL4448906 | — | — | 1 | 8.59 |
| CHEMBL4450301 | — | — | 1 | 8.57 |
| CHEMBL4558494 | — | — | 1 | 8.55 |
| CHEMBL4536396 | — | — | 1 | 8.52 |
| CHEMBL4556988 | — | — | 1 | 8.47 |
| CHEMBL4463007 | — | — | 1 | 8.46 |
| CHEMBL4550310 | — | — | 1 | 8.44 |
| CHEMBL4469844 | — | — | 1 | 8.41 |
| CHEMBL4574559 | — | — | 1 | 8.31 |
| CHEMBL4517586 | — | — | 1 | 8.22 |
| CHEMBL4467200 | — | — | 1 | 8.08 |
| CHEMBL4520559 | — | — | 1 | 7.80 |
| CHEMBL4587709 | — | — | 1 | 7.75 |
| CHEMBL4476445 | — | — | 1 | 7.47 |
| CHEMBL4463215 | — | — | 1 | 7.41 |
| CHEMBL4458055 | — | — | 1 | 7.40 |
| CHEMBL4438810 | — | — | 1 | 7.33 |
| CHEMBL4568482 | — | — | 1 | 7.31 |
| CHEMBL4476802 | — | — | 1 | 7.28 |
| CHEMBL4467503 | — | — | 1 | 7.23 |
| CHEMBL4549136 | — | — | 1 | 7.19 |
| CHEMBL4446722 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4526485 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4471599 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4482927 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4526498 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4443416 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4460058 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3393066 | VS-5584 | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL4536419 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL4448906 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4450301 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4558494 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL4536396 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4556988 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4463007 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4550310 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4469844 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4574559 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL4517586 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4467200 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4520559 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4587709 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4476445 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4463215 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4458055 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4438810 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4568482 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4476802 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4467503 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4549136 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4446722 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4536380 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4441275 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4440240 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4571980 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4441500 | — | IC50 | = | 490.0 | nM | 6.31 |