Assay Detail
Binding
CHEMBL4416477
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Inhibition of JAK1/3 in human Ramos cells harboring beta-lactamase reporter gene assessed as reduction in IL4-induced STAT6 phosphorylation incubated for 2 hrs by FRET assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Ramos |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.69 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463007 | — | — | 1 | 7.39 |
| CHEMBL4482927 | — | — | 1 | 7.36 |
| CHEMBL4526485 | — | — | 1 | 7.34 |
| CHEMBL4460058 | — | — | 1 | 7.17 |
| CHEMBL4526498 | — | — | 1 | 7.12 |
| CHEMBL4558494 | — | — | 1 | 7.02 |
| CHEMBL4536419 | — | — | 1 | 6.89 |
| CHEMBL4556988 | — | — | 1 | 6.89 |
| CHEMBL4517586 | — | — | 1 | 6.89 |
| CHEMBL4458055 | — | — | 1 | 6.85 |
| CHEMBL4463215 | — | — | 1 | 6.46 |
| CHEMBL4550310 | — | — | 1 | 6.12 |
| CHEMBL4476445 | — | — | 1 | 5.96 |
| CHEMBL4443416 | — | — | 1 | 5.47 |
| CHEMBL4587709 | — | — | 1 | 5.47 |
| CHEMBL4520559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463007 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4482927 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4526485 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4460058 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4526498 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4558494 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4536419 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4556988 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4517586 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4458055 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4463215 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4550310 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4476445 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4443416 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4587709 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4520559 | — | IC50 | - | — | - |