Assay Detail
Binding
CHEMBL4416568
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at beta2 adrenergic receptor in guinea pig tracheal smooth muscle assessed as inhibition of histamine-induced tracheal smooth muscle contraction by measuring spasmolysis preincubated for 15 mins in presence of beta adrenergic receptor antagonist propranolol followed by histamine addition
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Purification, and Selective β2-AR Agonist and Bronchodilatory Effects of Catecholic Tetrahydroisoquinolines from Portulaca oleracea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.58 | 8.10 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | 4.0 | 1 | 8.10 |
| CHEMBL298285 | — | — | 2 | 6.10 |
| CHEMBL4438390 | — | — | 2 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434 | ISOPROTERENOL | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL298285 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4438390 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4438390 | — | Inhibition | - | % | - | |
| CHEMBL298285 | — | Inhibition | - | % | - |