Assay Detail
Binding
CHEMBL4416608
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Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL3779755) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.09 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4559751 | — | — | 1 | 6.52 |
| CHEMBL4565429 | — | — | 1 | 6.51 |
| CHEMBL4570220 | — | — | 1 | 6.34 |
| CHEMBL4438030 | — | — | 1 | 6.33 |
| CHEMBL4469246 | — | — | 1 | 6.33 |
| CHEMBL4459483 | — | — | 1 | 6.26 |
| CHEMBL4437178 | — | — | 1 | 6.24 |
| CHEMBL4521108 | — | — | 1 | 6.21 |
| CHEMBL4543196 | — | — | 1 | 6.17 |
| CHEMBL4449341 | — | — | 1 | 6.16 |
| CHEMBL4520880 | — | — | 1 | 6.14 |
| CHEMBL4536818 | — | — | 1 | 6.11 |
| CHEMBL4454491 | — | — | 1 | 6.10 |
| CHEMBL4567140 | — | — | 1 | 6.06 |
| CHEMBL4456669 | — | — | 1 | 6.06 |
| CHEMBL4444873 | — | — | 1 | 6.05 |
| CHEMBL4457339 | — | — | 1 | 6.05 |
| CHEMBL4469806 | — | — | 1 | 6.04 |
| CHEMBL4460689 | — | — | 1 | 6.01 |
| CHEMBL4472886 | — | — | 1 | 5.97 |
| CHEMBL4445049 | — | — | 1 | 5.94 |
| CHEMBL4455922 | — | — | 1 | 5.89 |
| CHEMBL4471456 | — | — | 1 | 5.83 |
| CHEMBL4537830 | — | — | 1 | 5.83 |
| CHEMBL4457173 | — | — | 1 | 5.78 |
| CHEMBL4465138 | — | — | 1 | 5.75 |
| CHEMBL4568669 | — | — | 1 | 5.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4559751 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4565429 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4570220 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4438030 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4469246 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4459483 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4437178 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL4521108 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4543196 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4449341 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4520880 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4536818 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4454491 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4567140 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4456669 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4444873 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4457339 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4469806 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4460689 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4472886 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4445049 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4455922 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4471456 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4537830 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4457173 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4465138 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4568669 | — | IC50 | = | 1930.0 | nM | 5.71 |