Assay Detail
Binding
CHEMBL4416609
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs before compound addition with ATP for 30 mins by ELISA
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL3779755) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of Second-Generation NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 3 | - | - |
| IC50 | 2 | 6.60 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3183703 | — | — | 2 | 7.40 |
| CHEMBL4559751 | — | — | 2 | 5.80 |
| CHEMBL4455922 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3183703 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4559751 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL4455922 | — | Inhibition | - | % | - | |
| CHEMBL4559751 | — | Inhibition | - | % | - | |
| CHEMBL3183703 | — | Inhibition | - | % | - |