Assay Detail
Functional
CHEMBL4416669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human vincristine-rsistant KB/VJ300 cells assessed as reduction in cell growth after 72 hrs by MTT assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB/VJ300 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.79 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449333 | — | — | 1 | 6.70 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.40 |
| CHEMBL4460874 | — | — | 1 | 5.41 |
| CHEMBL4570692 | — | — | 1 | 5.38 |
| CHEMBL4568654 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449333 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4460874 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4570692 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4568654 | — | IC50 | = | 8800.0 | nM | 5.06 |