Assay Detail
Functional
CHEMBL4416670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human PC3 cells assessed as reduction in cell growth after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.27 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4435139 | — | — | 1 | 5.51 |
| CHEMBL4458301 | — | — | 1 | 5.21 |
| CHEMBL4449333 | — | — | 1 | 5.09 |
| CHEMBL4460874 | — | — | 1 | - |
| CHEMBL4568654 | — | — | 1 | - |
| CHEMBL4570692 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4435139 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4458301 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4449333 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4460874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4568654 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4570692 | — | IC50 | > | 10000.0 | nM | - |