Assay Detail
Binding
CHEMBL4416947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length human N-terminal GST-tagged HDAC6 expressed in baculovirus infected sf9 insect cells pretreated with compound followed by Fluor de Lys deacetylase substrate addition by fluorescence method
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574641 | — | — | 1 | 9.00 |
| CHEMBL4471726 | — | — | 1 | 8.70 |
| CHEMBL3655950 | — | — | 1 | 8.70 |
| CHEMBL4568509 | — | — | 1 | 8.52 |
| CHEMBL4456695 | — | — | 1 | 8.52 |
| CHEMBL4458053 | — | — | 1 | 8.52 |
| CHEMBL4440425 | — | — | 1 | 8.40 |
| CHEMBL4515782 | — | — | 1 | 8.40 |
| CHEMBL4589682 | — | — | 1 | 8.40 |
| CHEMBL4516856 | — | — | 1 | 8.30 |
| CHEMBL4434656 | — | — | 1 | 8.30 |
| CHEMBL4574536 | — | — | 1 | 8.30 |
| CHEMBL4475365 | — | — | 1 | 8.30 |
| CHEMBL4470373 | — | — | 1 | 8.30 |
| CHEMBL4466468 | — | — | 1 | 8.22 |
| CHEMBL4461219 | — | — | 1 | 8.22 |
| CHEMBL4524728 | — | — | 1 | 8.22 |
| CHEMBL4559109 | — | — | 1 | 8.22 |
| CHEMBL4470302 | — | — | 1 | 8.22 |
| CHEMBL4440341 | — | — | 1 | 8.15 |
| CHEMBL4453121 | — | — | 1 | 8.15 |
| CHEMBL4537736 | — | — | 1 | 8.10 |
| CHEMBL4551987 | — | — | 1 | 8.05 |
| CHEMBL4454663 | — | — | 1 | 8.05 |
| CHEMBL4514075 | — | — | 1 | 8.05 |
| CHEMBL4445138 | — | — | 1 | 8.05 |
| CHEMBL4548513 | — | — | 1 | 8.00 |
| CHEMBL4583522 | — | — | 1 | 8.00 |
| CHEMBL4580311 | — | — | 1 | 7.96 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574641 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4471726 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3655950 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4568509 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4456695 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4458053 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4589682 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4515782 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4440425 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4475365 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4470373 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4574536 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4434656 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4516856 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4470302 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4466468 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4559109 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4524728 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4461219 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4440341 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4453121 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4537736 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4445138 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4514075 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4551987 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4454663 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4548513 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4583522 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4580311 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4559028 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4556171 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4460868 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4438267 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4448410 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4535144 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4529251 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4439065 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL2179618 | NEXTURASTAT A | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4551484 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4454925 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4515650 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1213492 | GIVINOSTAT | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4464235 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4545033 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4550551 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL4436726 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL3970950 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4066043 | — | IC50 | = | 121.0 | nM | 6.92 |