Compound Detail
CHEMBL4470373
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Basic Information
| ChEMBL ID | CHEMBL4470373 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IAJVLFQKWJCAML-UHFFFAOYSA-N |
11
Targets
12
Activities
1
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
333.3
MW (Da)
0.58
ALogP
8
HBA
2
HBD
118.7
PSA (Ų)
0.53
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 12 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 6 CHEMBL1865 | IC50 | 8.3 | 8.3 | 5.0 | 2 |
| Histone deacetylase 9 CHEMBL4145 | IC50 | 6.32 | 6.32 | 480.0 | 1 |
| Histone deacetylase 8 CHEMBL3192 | IC50 | 6.3 | 6.3 | 504.0 | 1 |
| Histone deacetylase 4 CHEMBL3524 | IC50 | 6.25 | 6.25 | 562.0 | 1 |
| Histone deacetylase 7 CHEMBL2716 | IC50 | 6.14 | 6.14 | 727.0 | 1 |
| Histone deacetylase 5 CHEMBL2563 | IC50 | 5.55 | 5.55 | 2788.0 | 1 |
| Histone deacetylase 11 CHEMBL3310 | IC50 | 5.51 | 5.51 | 3071.0 | 1 |
| Histone deacetylase 1 CHEMBL325 | IC50 | 5.4 | 5.4 | 3960.0 | 1 |
| Histone deacetylase 3 CHEMBL1829 | IC50 | 5.29 | 5.29 | 5179.0 | 1 |
| Polyamine deacetylase HDAC10 CHEMBL5103 | IC50 | 5.04 | 5.04 | 9078.0 | 1 |
| Histone deacetylase 2 CHEMBL1937 | IC50 | 4.76 | 4.76 | 17196.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine