Assay Detail
Binding
CHEMBL4828683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human ful length N-terminal GST-tagged HDAC5 expressed in baculovirus expression system using Nepsilon-Trifluoroacetyl L-lysine as substrate by fluorescent microplate reader assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.68 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4862563 | — | — | 1 | 6.16 |
| CHEMBL4448410 | — | — | 1 | 5.69 |
| CHEMBL4470373 | — | — | 1 | 5.55 |
| CHEMBL4453121 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4862563 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL4448410 | — | IC50 | = | 2035.0 | nM | 5.69 |
| CHEMBL4470373 | — | IC50 | = | 2788.0 | nM | 5.55 |
| CHEMBL4453121 | — | IC50 | = | 4999.0 | nM | 5.30 |