Assay Detail
Binding
CHEMBL4828677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human C-terminal His-tagged HDAC1 expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor de Lys Green deacetylase as substrate by fluorescent microplate reader assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.33 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 7.16 |
| CHEMBL4870227 | — | — | 1 | 6.14 |
| CHEMBL4448410 | — | — | 1 | 6.03 |
| CHEMBL4453121 | — | — | 1 | 6.03 |
| CHEMBL4448978 | — | — | 1 | 5.72 |
| CHEMBL4852256 | — | — | 1 | 5.51 |
| CHEMBL4862508 | — | — | 1 | 5.49 |
| CHEMBL4470373 | — | — | 1 | 5.40 |
| CHEMBL154302 | — | — | 1 | 5.25 |
| CHEMBL4873055 | — | — | 1 | 5.17 |
| CHEMBL4862563 | — | — | 1 | 5.15 |
| CHEMBL155579 | — | — | 1 | 5.15 |
| CHEMBL4869421 | — | — | 1 | 5.13 |
| CHEMBL4864065 | — | — | 1 | 5.01 |
| CHEMBL4877419 | — | — | 1 | 4.94 |
| CHEMBL4863455 | — | — | 1 | 4.86 |
| CHEMBL4851389 | — | — | 1 | 4.80 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 4.60 |
| CHEMBL4850382 | — | — | 1 | 4.53 |
| CHEMBL504369 | NICOXAMAT | 2.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1213492 | GIVINOSTAT | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4870227 | — | IC50 | = | 718.0 | nM | 6.14 |
| CHEMBL4448410 | — | IC50 | = | 924.0 | nM | 6.03 |
| CHEMBL4453121 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4448978 | — | IC50 | = | 1914.0 | nM | 5.72 |
| CHEMBL4852256 | — | IC50 | = | 3064.0 | nM | 5.51 |
| CHEMBL4862508 | — | IC50 | = | 3211.0 | nM | 5.49 |
| CHEMBL4470373 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL154302 | — | IC50 | = | 5642.0 | nM | 5.25 |
| CHEMBL4873055 | — | IC50 | = | 6825.0 | nM | 5.17 |
| CHEMBL4862563 | — | IC50 | = | 7093.0 | nM | 5.15 |
| CHEMBL155579 | — | IC50 | = | 7138.0 | nM | 5.15 |
| CHEMBL4869421 | — | IC50 | = | 7394.0 | nM | 5.13 |
| CHEMBL4864065 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL4877419 | — | IC50 | = | 11378.0 | nM | 4.94 |
| CHEMBL4863455 | — | IC50 | = | 13812.0 | nM | 4.86 |
| CHEMBL4851389 | — | IC50 | = | 15797.0 | nM | 4.80 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 25380.0 | nM | 4.60 |
| CHEMBL4850382 | — | IC50 | = | 29367.0 | nM | 4.53 |
| CHEMBL504369 | NICOXAMAT | IC50 | = | 34958.0 | nM | 4.46 |