Compound Detail
CHEMBL504369
NICOXAMAT 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL504369 |
| Name | NICOXAMAT |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IYCHDNQCHLMLJZ-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
9
Publications
3
Known Names
Molecular Properties
138.1
MW (Da)
0.20
ALogP
3
HBA
2
HBD
62.2
PSA (Ų)
0.43
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 2 meas. best 6.17
EC50 1 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histone deacetylase 6 CHEMBL1865 | IC50 | 6.17 | 6.17 | 679.0 | 1 |
| Hepatitis C virus CHEMBL379 | EC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Histone deacetylase 1 CHEMBL325 | IC50 | 4.46 | 4.46 | 34958.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histone deacetylase 6 | IC50 | = | 679.0 | nM | 6.17 | Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expresse... | 34795871 |
| Hepatitis C virus | EC50 | = | 25000.0 | nM | 4.6 | Antiviral activity against HCV infected in human Huh-luc/neo7 cells after 72 hrs... | 25937017 |
| Histone deacetylase 1 | IC50 | = | 34958.0 | nM | 4.46 | Inhibition of recombinant human C-terminal His-tagged HDAC1 expressed in Sf9 ins... | 34795871 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19320487 | 10.1021/jm801475n | Unchecked | 1 |
| 25937017 | 10.1016/j.bmcl.2015.04.016 | Unchecked | 1 |
| 25937017 | 10.1016/j.bmcl.2015.04.016 | Hepatitis C virus | 1 |
| 25937017 | 10.1016/j.bmcl.2015.04.016 | ADMET | 1 |
| 25937017 | 10.1016/j.bmcl.2015.04.016 | Histone deacetylase 6 | 1 |
| 25937017 | 10.1016/j.bmcl.2015.04.016 | Histone deacetylase | 1 |
| 34795871 | 10.1021/acsmedchemlett.1c00425 | Histone deacetylase 1 | 1 |
| 34795871 | 10.1021/acsmedchemlett.1c00425 | Histone deacetylase 6 | 1 |
| 34795871 | 10.1021/acsmedchemlett.1c00425 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine