Assay Detail
Binding
CHEMBL4828678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length N-terminal GST-tagged HDAC6 expressed in Sf9 insect cells using Fluor de Lys deacetylase or Fluor de Lys Green deacetylase substrate by fluorescent microplate reader assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.14 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4470373 | — | — | 1 | 8.30 |
| CHEMBL4453121 | — | — | 1 | 8.15 |
| CHEMBL4870227 | — | — | 1 | 8.00 |
| CHEMBL4448410 | — | — | 1 | 7.77 |
| CHEMBL4862563 | — | — | 1 | 7.72 |
| CHEMBL1213492 | GIVINOSTAT | 4.0 | 1 | 7.64 |
| CHEMBL4863455 | — | — | 1 | 7.57 |
| CHEMBL4873055 | — | — | 1 | 7.31 |
| CHEMBL4862508 | — | — | 1 | 7.24 |
| CHEMBL4852256 | — | — | 1 | 7.19 |
| CHEMBL4877419 | — | — | 1 | 7.16 |
| CHEMBL4851389 | — | — | 1 | 6.95 |
| CHEMBL154302 | — | — | 1 | 6.85 |
| CHEMBL4448978 | — | — | 1 | 6.79 |
| CHEMBL4869421 | — | — | 1 | 6.74 |
| CHEMBL4864065 | — | — | 1 | 6.62 |
| CHEMBL155579 | — | — | 1 | 6.41 |
| CHEMBL4850382 | — | — | 1 | 6.34 |
| CHEMBL504369 | NICOXAMAT | 2.0 | 1 | 6.17 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4470373 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4453121 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4870227 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4448410 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4862563 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1213492 | GIVINOSTAT | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4863455 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4873055 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4862508 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4852256 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4877419 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4851389 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL154302 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4448978 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL4869421 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL4864065 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL155579 | — | IC50 | = | 389.0 | nM | 6.41 |
| CHEMBL4850382 | — | IC50 | = | 453.0 | nM | 6.34 |
| CHEMBL504369 | NICOXAMAT | IC50 | = | 679.0 | nM | 6.17 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 1343.0 | nM | 5.87 |