Assay Detail
Binding
CHEMBL4417039
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Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HUVEC |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.04 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572028 | — | — | 1 | 8.05 |
| CHEMBL4463138 | — | — | 1 | 7.92 |
| CHEMBL4591797 | — | — | 1 | 7.89 |
| CHEMBL4445117 | — | — | 1 | 7.85 |
| CHEMBL4553094 | — | — | 1 | 7.85 |
| CHEMBL4475680 | — | — | 1 | 7.82 |
| CHEMBL4550096 | — | — | 1 | 7.80 |
| CHEMBL4448724 | — | — | 1 | 7.75 |
| CHEMBL4464946 | — | — | 1 | 7.70 |
| CHEMBL4460444 | — | — | 1 | 7.52 |
| CHEMBL4448427 | — | — | 1 | 7.34 |
| CHEMBL4551283 | — | — | 1 | 7.31 |
| CHEMBL4451402 | — | — | 1 | 7.26 |
| CHEMBL4547442 | — | — | 1 | 7.17 |
| CHEMBL4450159 | — | — | 1 | 7.14 |
| CHEMBL4460950 | — | — | 1 | 6.96 |
| CHEMBL4522216 | — | — | 1 | 6.85 |
| CHEMBL4570368 | — | — | 1 | 6.77 |
| CHEMBL4454587 | — | — | 1 | 6.70 |
| CHEMBL4458906 | — | — | 1 | 6.31 |
| CHEMBL4566917 | — | — | 1 | 6.09 |
| CHEMBL4441643 | — | — | 1 | 6.05 |
| CHEMBL4575412 | — | — | 1 | 6.03 |
| CHEMBL4444681 | — | — | 1 | 5.96 |
| CHEMBL4473359 | — | — | 1 | 5.56 |
| CHEMBL4470242 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572028 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4463138 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4591797 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4445117 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4553094 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4475680 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4550096 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4448724 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4464946 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4460444 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4448427 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4551283 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4451402 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4547442 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL4450159 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4460950 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4522216 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4570368 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4454587 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4458906 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4566917 | — | IC50 | = | 809.0 | nM | 6.09 |
| CHEMBL4441643 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4575412 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4444681 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4473359 | — | IC50 | = | 2757.0 | nM | 5.56 |
| CHEMBL4470242 | — | IC50 | = | 4300.0 | nM | 5.37 |