Assay Detail
Binding
CHEMBL4417041
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 binding to recombinant full length N-terminal GFP-fused MetAP2 (unknown origin) expressed in HEK293 cells by Cheng-Prusoff equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor M8891: A Clinical Compound for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.92 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475680 | — | — | 1 | 9.80 |
| CHEMBL4451402 | — | — | 1 | 9.05 |
| CHEMBL4448724 | — | — | 1 | 8.47 |
| CHEMBL4464946 | — | — | 1 | 8.36 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475680 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL4451402 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL4448724 | — | Ki | = | 3.36 | nM | 8.47 |
| CHEMBL4464946 | — | Ki | = | 4.33 | nM | 8.36 |